反応 #696699

反応方程式

NaOH

3-(2-biphenylyl)-2-ethylpropionic acid

thionyl chloride

→

crude product

収率 106.3%

3-(2-biphenylyl)-2-ethylpropionyl chloride

収率 106.3%

反応条件

後処理

1. 1
   その他To a 100-ml three-necked round flask (equipped with a stirrer tip
2. 2
   温度were refluxed for 2.5 hours
3. 3
   温度with heating in a nitrogen atmosphere
4. 4
   workup.DISTILLATIONthe unreacted thionyl chloride was distilled off under reduced pressure

実験手順

To a 100-ml three-necked round flask (equipped with a stirrer tip, a Dimroth condenser, a thermometer and a trap of NaOH) were introduced 13.3 g (52.4 mmol) of 3-(2-biphenylyl)-2-ethylpropionic acid and 25.9 ml (355 mmol) of thionyl chloride, and they were refluxed for 2.5 hours with heating in a nitrogen atmosphere. After the reaction was completed, the unreacted thionyl chloride was distilled off under reduced pressure to obtain 15.2 g of a crude product as a yellow orange liquid. This acid chloride was used for the next reaction without further purification. The properties of the product thus obtained are described below.

出典