反応 #69632

反応方程式

ammonium chloride

ethanol

2,3-dichloro-6-nitrobenzaldehyde

sodium borohydride

→

2,3-dichloro-6-nitrobenzyl alcohol

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   抽出the solution was extracted three times with EtOAc
2. 2
   乾燥The combined organic layers were dried (MgSO4)
3. 3
   濃縮concentrated

実験手順

To a solution of 2,3-dichloro-6-nitrobenzaldehyde (7.62 g, 34.9 mmol) in tetrahydrofuran (75 mL) was added sodium borohydride (1.31 g, 34.9 mmol) followed by ethanol (1.75 mL), and the mixture was stirred for 1.5 hours. Saturated aqueous ammonium chloride (75 mL) was added, and the solution was extracted three times with EtOAc. The combined organic layers were dried (MgSO4) and then concentrated to give 2,3-dichloro-6-nitrobenzyl alcohol, as an oil which crystallised, 7.62 g (98%).

出典