反応 #69601

反応方程式

8-aminoquinoline

6

1-[Bromo(phenyl)methyl]-2-methylbenzene

6

1-[Bromo(phenyl)methyl]-2-methylbenzene

→

N-[(2-Methylphenyl)(phenyl)methyl]quinolin-8-amine

溶媒

triethylamine

triethylamine

triethylamine

反応条件

後処理

1. 1
   workup.STIRRINGThe resulting mixture was stirred for additional 2 hr at 120° C
2. 2
   workup.STIRRINGthe reaction mixture was stirred for 2 hr at 120° C
3. 3
   その他Finally, the product was isolated

実験手順

A mixture of 4.75 g (33 mmol) of 8-aminoquinoline, 3.03 g (30 mmol) of triethylamine and 7.85 g (30 mmol) of 6 was stirred for 2 hr at 120° C. One more portion of 3.03 g of triethylamine as well as 7.85 g of 6 was added. The resulting mixture was stirred for additional 2 hr at 120° C. Next, one more portion of triethylamine and 6 were added, and the reaction mixture was stirred for 2 hr at 120° C. Finally, the product was isolated using flash chromatography on silica gel 60 (40-63 um, eluent: hexanes-ethyl acetate=20:1, vol.). Yield 2.78 g (26%).

出典