反応 #69498

反応方程式

2-(benzylamino)ethanol

(R)-2-methyloxirane

→

(R)-1-(benzyl(2-hydroxyethyl)amino)propan-2-ol

収率 99.0%

反応条件

後処理

1. 1
   その他Excess of propylene oxide was removed under vacuum

実験手順

2-(benzylamino)ethanol (207 ml, 1454.97 mmol) and (R)-2-methyloxirane (153 ml, 2182.46 mmol) were mixed together and pumped at a flow rate of 1 mL/min through a 10 mL loop heated at 150° C. in a flow chemistry system. The back pressure regulator was adjusted in order to achieve a pressure inside the loop of 250 psi. Excess of propylene oxide was removed under vacuum to afford (R)-1-(benzyl(2-hydroxyethyl)amino)propan-2-ol (300 g, 99%) as a colourless liquid. Mass Spectrum: m/z [M+H]+=210.

出典