反応 #69481

反応方程式

tert-butyl 2-(6-(morpholine-4-carbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)-2,3-dihydro-1H-pyrrole-1-carboxylate

tert-butyl 2-(6-(morpholine-4-carbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate

→

tert-butyl 2-(6-(morpholine-4-carbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)pyrrolidine-1-carboxylate

収率 76.0%

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過The resulting solution was filtered
2. 2
   濃縮the filtrate was concentrated to dryness

実験手順

The above mixture of tert-butyl 2-(6-(morpholine-4-carbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)-2,3-dihydro-1H-pyrrole-1-carboxylate compound and tert-butyl 2-(6-(morpholine-4-carbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate (1:1) (2.1 g, 2.05 mmol) and platinum(IV) oxide (0.093 g, 0.41 mmol) in ethanol (30 ml) was hydrogenated under 1.2 atm at room temperature for 4 h. The resulting solution was filtered and the filtrate was concentrated to dryness to afford the crude tert-butyl 2-(6-(morpholine-4-carbonyl)-2-morpholino-4-oxo-4H-chromen-8-yl)pyrrolidine-1-carboxylate (1.60 g, 76%) as an orange solid. Mass Spectrum: m/z [M+H]+=514.

出典