反応 #6945

反応方程式

4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

DMF-DMA

→

desired product

4-(3-Dimethylamino-acryloyl)-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile

溶媒

acetonitrile

反応条件

後処理

1. 1
   温度the resulting mixture heated
2. 2
   温度at reflux for 18 hours
3. 3
   濃縮The reaction was concentrated
4. 4
   その他the residue triturated with diethyl ether (20 mL)
5. 5
   ろ過The suspension was filtered
6. 6
   洗浄washed with ether

実験手順

To a solution of 4-acetyl-3-methyl-5-methylsulfanyl-thiophene-2-carbonitrile (10 mmol) in acetonitrile (5 mL) was added DMF-DMA (2 mL) and the resulting mixture heated at reflux for 18 hours. The reaction was concentrated and the residue triturated with diethyl ether (20 mL). The suspension was filtered and washed with ether to afford the desired product as a yellow solid.

出典