反応 #69403

反応方程式

2-bromo-1-phenylethanone

3,4-diethoxybenzamide

NaHCO3

→

product

収率 17.0%

2-(3,4-diethoxyphenyl)-4-phenyloxazole

収率 17.0%

溶媒

DMF

反応条件

後処理

1. 1
   抽出extracted with EtOAc (50 ml×3)
2. 2
   洗浄The combined organic phases were washed with a saturated solution of NaCl (30 ml×2)
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他The product was purified by column chromatography

実験手順

In a microwave vial were dissolved 2-bromo-1-phenylethanone (95 mg, 0.478 mmol) and 3,4-diethoxybenzamide (100 mg, 0.478 mmol) in DMF (5 ml) and the reaction was heated at 170° C. for 40 min. The reaction mixture was poured in a saturated solution of NaHCO3 and extracted with EtOAc (50 ml×3). The combined organic phases were washed with a saturated solution of NaCl (30 ml×2) and concentrated under reduced pressure. The product was purified by column chromatography using CH2Cl2:MeOH (95:5) to yield 25 mg (17%) of the product. MS (EI) m/z: 310 (M+)

出典