反応 #69217

ord-09d002c7f53143179ef829fed499f57e

反応条件

温度
65°CELSIUS
詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    温度to cool to room temperature
  2. 2
    濃縮was concentrated in vacuo
  3. 3
    その他to give a dark oil
  4. 4
    その他The oil was partitioned between ethyl acetate and water
  5. 5
    洗浄The organic layer was washed with 1.0 N HCl, brine
  6. 6
    乾燥dried over magnesium sulfate
  7. 7
    濃縮concentrated
  8. 8
    その他to give a dark oil
  9. 9
    その他The viscous oil was triturated with ethyl ether 3×500 mL
  10. 10
    その他to give a dark precipitate
  11. 11
    その他to form a solid
  12. 12
    その他The solids were collected
  13. 13
    洗浄washed with ethyl ether
  14. 14
    その他dried

実験手順

4-(1H-Pyrazol-4-yl)-7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidine (31.0 g, 0.0983 mol) was suspended in ACN (620 mL, 12 mol), and DBU (9.3 mL, 0.062 mol) was added under nitrogen. The reaction was heated to 65° C. and dimethyl (2E)-pent-2-enedioate (16 mL, 0.12 mol) was added in 5 mL portions over 2 h. After stirring overnight, the reaction was complete. The reaction was allowed to cool to room temperature and was concentrated in vacuo to give a dark oil. The oil was partitioned between ethyl acetate and water. The organic layer was washed with 1.0 N HCl, brine, dried over magnesium sulfate, and then concentrated to give a dark oil. The viscous oil was triturated with ethyl ether 3×500 mL to give a dark precipitate. The oil was taken up in ethyl acetate to form a solid. The solids were collected, washed with ethyl ether and dried to give dimethyl 3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]pentanedioate as a white powder (29.5 gm, 64%), LC/MS (M+H)+: 474, 1H NMR (DMSO-d6) δ 9.1 (s,1H), 9.02 (s,1H), 8.65 (s, 1H), 8.11 (d, 1H), 7.42(d, 1H), 5.78(s, 2H), 5.27(m, 1H), 3.65(m, 8H), 3.15(m, 4H), 0.95(t, 2H), 0.1(s, 9H).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08530485B2uspto-grants-2013_09