反応 #6915

反応方程式

7-Amino-quinazolin-4-one

potassium iodide

sodium nitrite

→

title compound

収率 17.8%

7-Iodoquinazoline-4-one

収率 17.8%

溶媒

HCl

water

water

反応条件

後処理

1. 1
   温度cooled in an ice bath
2. 2
   その他partitioned between ethyl acetate and sodium thiosulphate
3. 3
   その他The organic phase was dried
4. 4
   濃縮concentrated in vacuo

実験手順

7-Amino-quinazolin-4-one (R. Dempsy and E. Skito, Biochemistry, 30, 1991, 8480) (1.61 g) was suspended in 6N HCl (20 ml) and cooled in an ice bath. A solution of sodium nitrite (0.75 g) in water (10 ml) was added dropwise over 15 minutes. After a further 10 minutes, a solution of potassium iodide (1.66 g) in water (5 ml) was added dropwise. The mixture was warmed to 20° C. and after 3 hours partitioned between ethyl acetate and sodium thiosulphate. The organic phase was dried and concentrated in vacuo to give the title compound (0.485 g); m/z (M+1+) 271.

出典