反応 #691384

反応方程式

pyridine

acetyl chloride

6-Aminohexanoic acid methyl ester hydrochloride

hydrochloric acid

→

methyl 6-acetylamino-hexanoate

溶媒

methylene chloride

chloroform

反応条件

後処理

1. 1
   その他the mixture is separated
2. 2
   洗浄the organic layer is washed with a saturated brine
3. 3
   乾燥dried over magnesium sulfate
4. 4
   濃縮concentrated under reduced pressure

実験手順

6-Aminohexanoic acid methyl ester hydrochloride (5 g) is dissolved in methylene chloride (20 ml) and thereto are added pyridine (4.5 ml) and acetyl chloride (2 ml), and the mixture is stirred at room temperature for 1 hour and 45 minutes. To the reaction solution are added a 1N-hydrochloric acid and chloroform, and the mixture is separated, and the organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give methyl 6-acetylamino-hexanoate (5.19 g) as a crude product. MS (m/z): 188 [M+H]+

出典