反応 #69128

反応方程式

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate

→

title compound

収率 61.0%

(R)-tert-butyl 1-(4-hydroxycyclohexyl)ethylcarbamate

収率 61.0%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過The rhodium catalyst was filtered off
2. 2
   濃縮the mother liquors were concentrated in vacuo
3. 3
   その他The residue was purified on silica gel by flash column chromatography

実験手順

(R)-tert-butyl 1-(4-hydroxyphenyl)ethylcarbamate (described in the literature: WO 2007035154 (A1)) (100 mg, 0.4214 mmol) was dissolved in methanol (5 mL). A methanolic (5 mL) solution of rhodium on alumina (10 Wt %, 10 mg) was added. The reaction mixture was place under a hydrogen atmosphere and stir at room temperature for 18 hours. The rhodium catalyst was filtered off and the mother liquors were concentrated in vacuo. The residue was purified on silica gel by flash column chromatography to afford the title compound (62 mg, 61% yield).

出典