反応 #6910

反応方程式

product

N-[1-(6-cyanoquinolin-2-yl)pyrrolidin-3-yl]-2,2-dimethylpropanamide

hydroxyl amine hydrochloride

sodium carbonate

→

N-(1-{6-[(Hydroxyamino)(imino)methyl]quinolin-2-yl}pyrrolidin-3-yl)-2,2-dimethylpropanamide

溶媒

dichloromethane

water

ethanol

反応条件

後処理

1. 1
   洗浄washed twice with brine
2. 2
   乾燥dried over sodium sulfate
3. 3
   ろ過filtered through a fritted funnel
4. 4
   その他the volatiles were removed under vacuum
5. 5
   その他This provided the product, MS
6. 6
   その他m/z 356, which was used in the next step without further purification

実験手順

A mixture of the product of Step D (60 mg; 0.1863 mmol), hydroxyl amine hydrochloride (3 eq.), sodium carbonate (4 eq.) in 1.5 mL water and 2.5 mL ethanol was heated to 90° C. for 6 h. The mixture was diluted with dichloromethane, washed twice with brine, dried over sodium sulfate, filtered through a fritted funnel and the volatiles were removed under vacuum. This provided the product, MS: m/z 356, which was used in the next step without further purification.

出典