反応 #6908

反応方程式

3,4-Dihydroquinolin-2(1H)-one

iodine

→

title compound

6-Iodo-3,4-dihydroquinolin-2(1H)-one

溶媒

ethanol

ethanol

反応条件

後処理

1. 1
   ろ過the reaction was filtered through CELITE diatomaceous earth
2. 2
   洗浄washed copiously with methanol
3. 3
   その他The volatiles were removed under vacuum
4. 4
   その他the crude residue was triturated with ether
5. 5
   その他The solids were collected on a fritted funnel
6. 6
   その他dried under vacuum

実験手順

3,4-Dihydroquinolin-2(1H)-one (7.5 g; 51 mmol) and silver (I) sulfate (17.5 g; 56.1 mmol) were suspended in ethanol (250 mL). A solution of iodine in ethanol (250 mL) was added slowly to the reaction over 1 hour. After 6 hours, the reaction was filtered through CELITE diatomaceous earth and washed copiously with methanol. The volatiles were removed under vacuum and the crude residue was triturated with ether. The solids were collected on a fritted funnel and dried under vacuum. This provided the title compound.

出典