反応 #6907

反応方程式

2-iodoaniline

dimethylmaleate

triethylamine

→

methyl 2-oxo-1,2-dihydroquinoline-4-carboxylate

溶媒

acetonitrile

反応条件

後処理

1. 1
   その他The tube was flushed with nitrogen
2. 2
   その他sealed
3. 3
   温度The sealed tube was heated at 100° for 3.5 h
4. 4
   ろ過the resulting solids filtered
5. 5
   洗浄washed with acetonitrile
6. 6
   workup.DISSOLUTIONThe solids were dissolved in chloroform
7. 7
   その他the solvent removed under vacuum
8. 8
   その他to provide a solid

実験手順

In a heavy-walled PYREX tube was placed 2-iodoaniline (2.84 g, 13 mmol), dimethylmaleate (2.44 g, 17 mmol), triethylamine (1.4 mL, 10 mmol), palladium diacetate (31 mg, 0.14 mmol) and 6 mL acetonitrile. The tube was flushed with nitrogen and sealed. The sealed tube was heated at 100° for 3.5 h then cooled to r.t. The tube was opened and the resulting solids filtered and washed with acetonitrile. The solids were dissolved in chloroform and the solvent removed under vacuum to provide a solid.

出典