反応 #69007

反応方程式

2-chloro-4-methoxypyrimidine

4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline

→

4-methoxy-N-(4-(3-methyl-1H-1,2,4-triazol-1-yl)phenyl)pyrimidin-2-amine

溶媒

ethoxyethanol

water

EtOAc

反応条件

後処理

1. 1
   温度cooled
2. 2
   その他The layers were separated
3. 3
   抽出the aqueous layer was extracted with EtOAc (4×)
4. 4
   乾燥The combined organics were dried (MgSO4)
5. 5
   濃縮concentrated
6. 6
   その他to give a near colorless solid which
7. 7
   その他was used without further purification

実験手順

To a solution 2-chloro-4-methoxypyrimidine (2 g, 13.8 mmol) in ethoxyethanol (50 mL) was added 4-(3-methyl-1H-1,2,4-triazol-1-yl)aniline (1.7 g, 10.6 mmol). The reaction was warmed to 75° C. for 16 h, cooled, and diluted with water and EtOAc. The layers were separated, and the aqueous layer was extracted with EtOAc (4×). The combined organics were dried (MgSO4), and concentrated to give a near colorless solid which was homogeneous by analytical HPLC analysis and was used without further purification.

出典