反応 #68972

反応方程式

water

1-(4-Bromophenyl)piperazine

triethylamine

methanesulfonyl chloride

→

1-(4-bromophenyl)-4-methanesulfonylpiperazine

収率 99.9%

溶媒

dichloromethane

反応条件

後処理

1. 1
   温度is maintained for 16 h
2. 2
   workup.STIRRINGstirring
3. 3
   洗浄the organic phase is washed with a saturated aqueous sodium chloride solution
4. 4
   乾燥dried over MgSO4
5. 5
   濃縮concentrated

実験手順

1-(4-Bromophenyl)piperazine (5 g, 20.7 mmol) is placed in 104 ml of dichloromethane and then triethylamine (4.34 ml, 31.1 mmol) is added, followed, dropwise, by methanesulfonyl chloride (1.93 ml, 24.9 mmol). Stirring is maintained for 16 h. After the addition of 30 ml of water and stirring, the organic phase is washed with a saturated aqueous sodium chloride solution, dried over MgSO4 and concentrated. 6.6 g of expected 1-(4-bromophenyl)-4-methanesulfonylpiperazine are obtained.

出典