反応 #6893

反応方程式

(2E)-3-(4-chlorophenyl)prop-2-enoic acid

oxalyl chloride

N,N-dimethylformamide

→

(2E)-3-(4-chlorophenyl)prop-2-enoyl chloride

溶媒

methylene chloride

反応条件

後処理

1. 1
   その他The solvent was removed under vacuum
2. 2
   workup.ADDITIONThe resulting solid was diluted with hexanes
3. 3
   その他the solvent removed under vacuum
4. 4
   その他to provide an off-white solid which
5. 5
   その他was used without further purification

実験手順

To a solution of (2E)-3-(4-chlorophenyl)prop-2-enoic acid (2.0 g, 11 mmol) in 50 mL methylene chloride was added oxalyl chloride (1.05 mL, 12.1 mmol) and N,N-dimethylformamide (0.05 mL, 0.6 mmol). The resulting mixture was stirred at r.t. for 6 h. The solvent was removed under vacuum. The resulting solid was diluted with hexanes and the solvent removed under vacuum to provide an off-white solid which was used without further purification.

出典