反応 #68927

反応方程式

2-Methyl-4-oxiranylmethoxy-1H-indole

7-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-7,9-diaza-bicyclo[4.2.2]dec-3-ene

chloroform

→

title compound

1-[9-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7,9-diaza-bicyclo[4.2.2]dec-3-en-7-yl]-3-(2-methyl-1H-indol-4-yloxy)-propan-2-ol

溶媒

ethanol

反応条件

後処理

1. 1
   その他at 130° C.
2. 2
   その他The solvent was evaporated under reduced pressure
3. 3
   その他to yield a crude solid
4. 4
   その他that was purified with flash chromatography gradient [20% Ethyl acetate/heptane to 100% Ethyl acetate]

実験手順

2-Methyl-4-oxiranylmethoxy-1H-indole (25 mg, 0.123 mmol), 7-(2,3-dihydro-benzo[1,4]dioxin-6-yl)-7,9-diaza-bicyclo[4.2.2]dec-3-ene (34 mg, 0.125 mmol), chloroform (1 mL), ethanol (3 mL) were heated for 900 sec. at 130° C. in a μW reaction tube. The solvent was evaporated under reduced pressure to yield a crude solid that was purified with flash chromatography gradient [20% Ethyl acetate/heptane to 100% Ethyl acetate] to yield the title compound as a residue.

出典