反応 #68850

反応方程式

Ethyliodide

4-bromo-5-fluoro-pyridin-2-ol

→

4-Bromo-2-ethoxy-5-fluoropyridine

溶媒

DCM

反応条件

後処理

1. 1
   その他Then the reaction mixture is quenched by the addition of water and DCM
2. 2
   ろ過After filtration the org
3. 3
   その他layer is separated
4. 4
   乾燥dried with Na2SO4
5. 5
   その他the solvent is removed in vacuo

実験手順

2.08 mL (26.0 mmol) Ethyliodide and 1.08 g (3.91 mmol) Ag2CO3 are added to a mixture of 500 mg (2.160 mmol) 4-bromo-5-fluoro-pyridin-2-ol in 10 mL DCM. The mixture is stirred at r.t. over night. Then the reaction mixture is quenched by the addition of water and DCM. After filtration the org. layer is separated, dried with Na2SO4 and the solvent is removed in vacuo.

出典