反応 #68840

反応方程式

5-bromo-2-chloropyrimidine

cyclobutylamin

DIPEA

ACN

→

5-Bromo-N-cyclobutylpyrimidin-2-amine

溶媒

EtOAc

反応条件

後処理

1. 1
   洗浄washed with water (2×)
2. 2
   乾燥phase is dried with MgSO4
3. 3
   その他the solvent is removed in vacuo

実験手順

In a sealed tube 2.00 g (10.3 mmol) 5-bromo-2-chloropyrimidine, 1.15 mL (13.4 mmol) cyclobutylamin and 2.70 mL (15.5 mmol) DIPEA are added to 12 mL ACN. The reaction mixture is stirred at 50° C. over night, then diluted with EtOAc and washed with water (2×). The org. phase is dried with MgSO4 and the solvent is removed in vacuo.

出典