反応 #68838

反応方程式

4-bromophenol

(chloromethyl)cyclopropane

K2CO3

DMF

→

1-Bromo-4-cyclopropylmethoxybenzene

溶媒

water

反応条件

後処理

1. 1
   抽出extracted with DCM
2. 2
   乾燥The organic layer is dried with MgSO4
3. 3
   その他the solvent is removed in vacuo

実験手順

5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried with MgSO4 and the solvent is removed in vacuo.

出典