反応 #68747

反応方程式

2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone

→

2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione

溶媒

acetone

hydrochloric acid

water

hydrochloric acid

反応条件

後処理

1. 1
   抽出the crude product is extracted with ethyl acetate (3×15 ml)
2. 2
   洗浄washed with brine (10 ml)
3. 3
   乾燥dried over anhydrous magnesium sulfate
4. 4
   ろ過filtered
5. 5
   その他the filtrate is evaporated to dryness under reduced pressure

実験手順

A solution of 2-(4′-chloro-4-ethylbiphen-3-yl)-3-methoxycyclopent-2-enone (200 mg, 0.61 mmol) in acetone (4 ml) and 2M aqueous hydrochloric acid (4 ml) is heated at 120° C. for 20 minutes under microwave irradiation. The reaction mixture is diluted with water (20 ml) and 2M aqueous hydrochloric acid (10 ml), and the crude product is extracted with ethyl acetate (3×15 ml). The organic extracts are combined, washed with brine (10 ml), dried over anhydrous magnesium sulfate, filtered and the filtrate is evaporated to dryness under reduced pressure to give 2-(4′-chloro-4-ethylbiphen-3-yl)-1,3-cyclopentanedione.

出典