反応 #68718

ord-361d423c474e44afb7ab249f0c11104c

反応方程式

C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
calcitriol
CCO
ethanol
C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
calcitriol
CC(C)=O
acetone
→
C=C1CC[C@H](O)C/C1=C/C=C1\CCC[C@]2(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]12
calcifediol

反応物

C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
calcitriol
CCO
ethanol
C=C1/C(=C\C=C2/CCC[C@]3(C)[C@@H]([C@H](C)CCCC(C)(C)O)CC[C@@H]23)C[C@@H](O)C[C@@H]1O
calcitriol
CC(C)=O
acetone

試薬

なし

溶媒

CS(C)=O
DMSO

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他yields of 74.87 mg/L and 70.85 mg/L

実験手順

Also, when a mass-production was carried out by varying the kinds of an organic solvent, ethanol showed a calcitriol production yield of 48.45 mg/L, and acetone and DMSO showed calcitriol production yields of 74.87 mg/L and 70.85 mg/L, respectively, and calcifediol production yields of 156.37 mg/L and 141.81 mg/L, respectively. Especially, methanol showed a calcitriol production yield of 90.12 mg/L, and a calcifediol production yield of 166.87 mg/L (see Example 9). Accordingly, it can be seen that the inventive composition including methanol, ethanol, acetone, and DMSO showed a high calcitriol or calcifediol productivity.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08530205B2uspto-grants-2013_09