反応 #6866

反応方程式

product

Methyl 4-Imidazoleacetate

chlorotriphenylmethane

Et3N

→

product

収率 104.0%

Methyl 1-triphenylmethyl-4-imidazoleacetate

収率 104.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他The DMF was evaporated under reduced pressure
2. 2
   乾燥The EtOAc layer was dried over Na2SO4
3. 3
   ろ過filtered
4. 4
   濃縮concentrated under reduced pressure

実験手順

A solution of the product from Step 4.a. (3.2 g, 17.5 mmol) in DMF (50 ml) was treated with chlorotriphenylmethane (4.88 g, 17.5 mmol) and Et3N (5.4 ml, 38.5 mmol) and the reaction was stirred at room temperature for about 6 hours. The DMF was evaporated under reduced pressure and the residue was distributed between EtOAc and saturated NaCl solution. The EtOAc layer was dried over Na2SO4, filtered and concentrated under reduced pressure to yield product as a viscous oil (6.96 g, 104%) which crystallized on standing. Mass spec. 383.3 MH+.

出典