反応 #6861

反応方程式

MeOH

Urocanic acid

compound i

Urocanic acid

→

3-(1H-Imidazol-5-yl)-propionic acid

溶媒

HCl

反応条件

後処理

1. 1
   その他The catalyst was removed by filtration through a 3 cm pad of diatomaceous earth
2. 2
   濃縮the filtrate was concentrated to a solid
3. 3
   その他dried overnight under vacuum
4. 4
   その他The crude material was used without further purification

実験手順

Urocanic acid (compound i, where R2 is H)(1.38 g, 10.0 mmol) was dissolved in 5% aqueous HCl (20 ml) plus MeOH (15 ml) containing 10% Pd on carbon (100 mg) and the mixture was shaken overnight under about 30 psi H2. The catalyst was removed by filtration through a 3 cm pad of diatomaceous earth and the filtrate was concentrated to a solid and dried overnight under vacuum. The crude material was used without further purification. Mass spec. 141.4 MH+

出典