反応 #685701

反応方程式

2,4,5-trifluoroaniline

potassium ethylxanthogenate

HCl

→

titled compound

収率 40.0%

5,6-Difluoro-benzothiazole-2-thiol

収率 40.0%

溶媒

N,N-dimethylformamide

water

反応条件

後処理

1. 1
   温度The reaction mixture was cooled to room temperature
2. 2
   ろ過The precipitate was collected by filtration
3. 3
   洗浄washed with water
4. 4
   その他dried

実験手順

A mixture of 1 g (6.80 mmol) 2,4,5-trifluoroaniline and 1.33 g (8.16 mmol) potassium ethylxanthogenate in 5 mL dry N,N-dimethylformamide was heated in a 95° C. oil bath for 7 h. The reaction mixture was cooled to room temperature and diluted with water (15 mL). The mixture was acidified with aqueous HCl 2N. The precipitate was collected by filtration, washed with water and dried to provide 0.55 g (40%) of the titled compound as a light yellow solid. MS(m/e): 201.9 (M−H+).

出典