反応 #68558

反応方程式

4-bromo-2-chlorobenzaldehyde

(r)-(+)-2-methyl-2-propanesulfinamide

→

(R,Z)—N-(4-bromo-2-chlorobenzylidene)-2-methylpropane-2-sulfinamide

溶媒

DCM

反応条件

後処理

1. 1
   その他Reaction
2. 2
   ろ過filtered through Celite, and solid
3. 3
   洗浄washed repeatedly with DCM
4. 4
   濃縮Filtrate concentrated
5. 5
   その他then purified on silica (80 g)
6. 6
   洗浄eluting product with 0>30% of EtOAc/Hex

実験手順

A suspension of 4-bromo-2-chlorobenzaldehyde (1150 mg, 5240 μmol), (r)-(+)-2-methyl-2-propanesulfinamide (1588 mg, 13100 μmol), copper(ii) sulfate (696.4 μl, 15720 μmol) in DCM (10 mL) was stirred at 37° C. for 78 h. Reaction filtered through Celite, and solid washed repeatedly with DCM. Filtrate concentrated then purified on silica (80 g) eluting product with 0>30% of EtOAc/Hex. MS (ESI pos. ion) m/z: 322/324 (MH+). Calc'd exact mass for C11H13BrClNOS: 321/323.

出典