反応 #68534

反応方程式

ammonia

3-Bromo-5-methoxypyridine

NaOH

→

3-amino-5-methoxypyridine

反応条件

後処理

1. 1
   温度cooled to RT
2. 2
   抽出extracted with CH2Cl2
3. 3
   その他After evaporation of volatiles

実験手順

3-Bromo-5-methoxypyridine (15 g) was added to a pressure vessel, and CuSO4 (3.9 g) and 25% aq ammonia (150 mL) were added. The reaction mixture was stirred for 4 h at 135° C., then cooled to RT, basified with aqueous NaOH solution, and extracted with CH2Cl2. After evaporation of volatiles, 3-amino-5-methoxypyridine was obtained as yellow solid.

出典