反応 #684981

反応方程式

Trifluoroacetic acid

(4-(dodecanoylsulfamoyl)benzyl)carbamic acid tert-butyl ester

→

trifluoroacetic salt

収率 128.9%

4-Aminomethyl-N-(dodecanoyl)benzenesulfonamide

収率 128.9%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他was at room temperature
2. 2
   その他The solvents were removed in vacuo
3. 3
   workup.DISSOLUTIONThe residue was dissolved in dichloromethane (40 ml)
4. 4
   その他the solvent was removed in vacuo

実験手順

Trifluoroacetic acid (25 ml) was at room temperature added to a solution of (4-(dodecanoylsulfamoyl)benzyl)carbamic acid tert-butyl ester (170 mg, 0.40 mmol) in dichloromethane (25 ml). The reaction mixture was stirred for 1 h at room temperature. The solvents were removed in vacuo. The residue was dissolved in dichloromethane (40 ml) and the solvent was removed in vacuo. The latter procedure was repeated once to give 0.19 g of the trifluoroacetic salt of 4-aminomethyl-N-(dodecanoyl)benzenesulfonamide.

出典