反応 #684980

反応方程式

N-bromosuccinimide

N-dodecanoyl-4-methylbenzenesulfonamide

Ethyl acetate

heptane

→

4-bromomethyl-N-(dodecanoyl)benzenesulfonamide

収率 120.2%

溶媒

tetrachloromethane

反応条件

後処理

1. 1
   温度The reaction mixture was heated for 1 h to 80° C
2. 2
   温度The reaction mixture was heated another 2 h to 80° C
3. 3
   その他The solid was removed by filtration
4. 4
   その他The solvent was removed from the filtrate

実験手順

At 80° C., N-bromosuccinimide (1.43 g, 8.06 mmol) and dibenzoylperoxide (62 mg, 0.25 mmol) were added successively to a solution of N-dodecanoyl-4-methylbenzenesulfonamide (3 g, 8.48 mmol) in tetrachloromethane (75 ml). The reaction mixture was heated for 1 h to 80° C. Another portion of dibenzoylperoxide (100 mg, 0.41 mmol) was added. The reaction mixture was heated another 2 h to 80° C. It was cooled to room temperature and left for 16 h. Ethyl acetate (100 ml) and heptane (100 ml) were added. The solid was removed by filtration. The solvent was removed from the filtrate to give 4.19 g of crude 4-bromomethyl-N-(dodecanoyl)benzenesulfonamide, which was used for the next step, without further purification.

出典