反応 #684979

反応方程式

4-sulfamoylbutyric acid

trimethylorthoformate

→

ester

収率 99.0%

4-sulfamoylbutyric acid methyl ester

収率 99.0%

溶媒

methanol

反応条件

後処理

1. 1
   濃縮concentrated

実験手順

A mixture of 4-sulfamoylbutyric acid (2.53 g, 15.1 mmol), methanol (25 ml), trimethylorthoformate (10 ml, approx 5 eq) and polystyrene-bound toluenesulfonic acid (0.58 g) was stirred at 60° C. After 19 h the mixture was decantated from the catalyst and concentrated to yield 2.70 g (99%) of the title ester as an oil.

出典