反応 #684975

反応方程式

ethyl acetate

Potassium carbonate

methyl iodide

compound

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

→

title compound

収率 84.4%

2-(4-Bromo-2-fluorobenzyl)-3-methoxypyridine

収率 84.4%

溶媒

dimethylformamide

反応条件

後処理

1. 1
   洗浄the reaction mixture was washed with saturated brine
2. 2
   濃縮concentrated under reduced pressure
3. 3
   その他The residue was purified by silica gel column chromatography

実験手順

Potassium carbonate (38.7 mg, 0.280 mmol) and methyl iodide (10.5 μl, 0.168 mmol) were added to a solution of the compound of Example B245 (15.8 mg, 0.0560 mmol) in dimethylformamide (1 ml), and this reaction mixture was stirred at room temperature for 2 hours. After ethyl acetate was added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (14.0 mg).

出典