反応 #684974

反応方程式

ethyl acetate

Trifluoroacetic acid

compound

2-(4-Bromo-2-fluorobenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

→

title compound

収率 84.1%

2-(4-Bromo-2-fluorobenzyl)-3-pyridinol

収率 84.1%

溶媒

methylene chloride

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   洗浄The ethyl acetate layer was washed with saturated brine
3. 3
   濃縮concentrated under reduced pressure
4. 4
   その他The residue was purified by silica gel column chromatography

実験手順

Trifluoroacetic acid (1 ml) was added to the compound of Example B244 (134 mg, 0.411 mmol) in methylene chloride (4 ml), and this reaction mixture was stirred at room temperature overnight. After neutralizing the mixture with saturated aqueous sodium hydrogencarbonate, ethyl acetate was added. The ethyl acetate layer was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (97.5 mg).

出典