反応 #684971

反応方程式

Trifluoroacetic acid

compound

2-(4-Butylbenzyl)-3-(methoxymethoxy)pyridine

sodium hydrogencarbonate

ethyl acetate

→

title compound

収率 88.8%

2-(4-Butylbenzyl)-3-pyridinol

収率 88.8%

溶媒

methylene chloride

反応条件

後処理

1. 1
   洗浄the reaction mixture was washed with saturated brine
2. 2
   濃縮concentrated under reduced pressure
3. 3
   その他The residue was purified by silica gel column chromatography

実験手順

Trifluoroacetic acid (1 ml) was added to a solution of the compound of Example B229 (256 mg, 0.849 mmol) in methylene chloride (5 ml), and this reaction mixture was stirred at room temperature overnight. After a saturated aqueous sodium hydrogencarbonate solution and ethyl acetate were added, the reaction mixture was washed with saturated brine and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (182 mg).

出典