反応 #684970

反応方程式

Potassium carbonate

methyl iodide

compound

1-(4-Bromo-2-hydroxyphenyl)-1-butanone

→

title compound

収率 67.7%

1-(4-Bromo-2-methoxyphenyl)-1-butanone

収率 67.7%

溶媒

acetone

反応条件

後処理

1. 1
   温度while heating
2. 2
   温度under reflux for 4 hours
3. 3
   ろ過The reaction mixture was filtered through celite, ether
4. 4
   workup.ADDITIONwas added
5. 5
   その他to remove insoluble material
6. 6
   ろ過by filtration
7. 7
   濃縮the filtrate was concentrated under reduced pressure
8. 8
   その他The residue was purified by silica gel column chromatography

実験手順

Potassium carbonate (9.07 g) and methyl iodide (3.92 ml) were added to a solution of the compound of Example B220 (13.30 g) in acetone (75 ml), and this reaction mixture was stirred while heating under reflux for 4 hours. The reaction mixture was filtered through celite, ether was added to remove insoluble material by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (9.52 g).

出典