反応 #684969

反応方程式

Water

ethyl acetate

1-hydroxyisoquinoline

Bromine

→

title compound

収率 80.1%

4-Bromo-1-isoquinolinol

収率 80.1%

溶媒

tetrahydrofuran

acetic acid

反応条件

後処理

1. 1
   その他the resulting reaction mixture
2. 2
   ろ過was filtered
3. 3
   ろ過through filter paper
4. 4
   洗浄The organic layer was washed with saturated brine
5. 5
   濃縮concentrated under reduced pressure
6. 6
   その他The residue was recrystallized from ethyl acetate and hexane

実験手順

Bromine (1.78 ml, 34.5 mmol) was added to an ice-cooled solution of 1-hydroxyisoquinoline (5.01 g, 34.5 mmol) in acetic acid (50 ml), and this reaction mixture was stirred at room temperature for 2 hours. Water, ethyl acetate, and tetrahydrofuran were added, and the resulting reaction mixture was filtered through filter paper. The organic layer was washed with saturated brine and concentrated under reduced pressure. The residue was recrystallized from ethyl acetate and hexane to give the title compound (6.19 g).

出典