反応 #684962

反応方程式

ammonium formate

compound

1-(3-Methoxyphenyl)-2-nitro-1-ethanol

→

title compound

収率 72.6%

2-Amino-1-(3-methoxyphenyl)-1-ethanol

収率 72.6%

溶媒

tetrahydrofuran

methanol

反応条件

後処理

1. 1
   その他The catalyst was removed by filtration
2. 2
   workup.ADDITIONthe filtrate was diluted with ether
3. 3
   その他precipitates
4. 4
   その他were removed by filtration
5. 5
   濃縮the obtained filtrate was concentrated

実験手順

Palladium-carbon (10%, 0.64 g) and ammonium formate (4.8 g) were added to a mixed solution of the compound of Example B142 (3.0 g, 15 mmol) in tetrahydrofuran (43 ml) and methanol (43 ml), and this mixture was stirred at room temperature for 18 hours. The catalyst was removed by filtration, the filtrate was diluted with ether, precipitates were removed by filtration, and the obtained filtrate was concentrated to give the title compound (1.82 g). This compound was used in the following reaction without further purification.

出典