反応 #6838

反応方程式

Acetic acid

3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride

Propionaldehyde

→

2,3,4,9-tetrahydro-1H-β-carbolin-6-ol

溶媒

methanol

反応条件

後処理

1. 1
   温度The tube was cooled to rt
2. 2
   その他The solvent was evaporated

実験手順

Acetic acid was added dropwise to a solution of 3-(2-amino-ethyl)-1H-indol-5-ol hydrochloride (200 mg) in 7 mL methanol until the pH=4. Propionaldehyde (0.2 mL) was added and the mixture was heated at 75° C. in a sealed tube for 1 h. The tube was cooled to rt and unsealed. The solvent was evaporated to yield 190 mg of 2,3,4,9-tetrahydro-1H-β-carbolin-6-ol.

出典