反応 #6834

反応方程式

Diisobutylaluminum hydride

2-(6-methoxy-1H-indol-3-yl)ethylamine

→

3-(2-amino-ethyl)-1H-indol-6-ol

収率 68.2%

溶媒

toluene

反応条件

後処理

1. 1
   温度The resulting clear solution was refluxed for 10 h
2. 2
   その他quenched by the careful addition of 20 mL of 1:1 methyl alcohol
3. 3
   ろ過filtered
4. 4
   その他to remove the precipitated aluminum salts
5. 5
   その他The solvent was evaporated

実験手順

Diisobutylaluminum hydride (1 M in toluene, 15 mL) was slowly added to a suspension of 2-(6-methoxy-1H-indol-3-yl)ethylamine (250 mg) in 20 mL of toluene. The resulting clear solution was refluxed for 10 h, then cooled to 0° C. and quenched by the careful addition of 20 mL of 1:1 methyl alcohol:water. The mixture was stirred for 15 min at rt and filtered to remove the precipitated aluminum salts. The solvent was evaporated to yield 158 mg of 3-(2-amino-ethyl)-1H-indol-6-ol.

出典