反応 #68309

反応方程式

2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol

Compound 3

2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol

HCl Et2O

→

crude title compound

1-Benzyl-2-isopropyl-6-methoxy-1H-indole

溶媒

EtOAc

EtOH

反応条件

後処理

1. 1
   ろ過was filtered
2. 2
   workup.ADDITIONTo the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml)
3. 3
   ろ過This was then filtered
4. 4
   濃縮concentrated in vacuo

実験手順

To a solution of 2-(1-benzyl-6-methoxy-1H-indol-2-yl)propan-2-ol (Compound 3, 1.05 g, 3.57 mmol) in EtOAc (35 ml) and EtOH (15 ml) was added 10% Pd—C (190 mg, 0.18 mmol) and HCl-Et2O (1.0 M, 1.25 ml, 1.25 mmol). The mixture was stirred under hydrogen gas (atmospheric pressure) for 1 h and was filtered. To the filtrate was added NaHCO3 (0.5 g) and H2O (0.5 ml), followed by Na2SO4 and MgSO4. This was then filtered and concentrated in vacuo to yield the crude title compound as a yellow solid.

出典