反応 #680500

反応方程式

sodium hydroxide

bis(3-chloro-2-hydroxypropyl)disulfide

methanol

→

bis(β-epoxypropyl)disulfide

溶媒

toluene

toluene

反応条件

後処理

1. 1
   その他was dripped into a reaction vessel
2. 2
   workup.ADDITIONcontaining a mixed solvent
3. 3
   抽出extraction
4. 4
   その他the aqueous layer was removed
5. 5
   洗浄the organic layer was washed with 180 g of water three times
6. 6
   workup.DISTILLATIONAfter that, the solvent was distilled away

実験手順

Next, a mixed solution of bis(3-chloro-2-hydroxypropyl)disulfide described above and 250 g of methanol was dripped into a reaction vessel containing a mixed solvent consisting of 500 g of toluene and 240 g of 47% aqueous solution of sodium hydroxide with the temperature of the solution in the reaction vessel being maintained at 0 to 10° C. At the point of the completion, no scum-like insoluble matter was generated. 100 g of toluene was added to carry out extraction, the aqueous layer was removed, and the organic layer was washed with 180 g of water three times. After that, no scum-like insoluble matter was generated. After that, the solvent was distilled away, thereby obtaining 171 g of bis(β-epoxypropyl)disulfide.

出典