反応 #68004

反応方程式

trifluoroacetic acid

1-(1,3-dioxolan-2-ylmethyl)-4-chloroquinolin-2(1H)-one

→

(4-chloro-2-oxoquinolin-1(2H)-yl)acetaldehyde

反応条件

後処理

1. 1
   その他The solvent was removed under reduced pressure
2. 2
   抽出extracted with ethyl acetate
3. 3
   洗浄The organic layer was washed sequentially with water
4. 4
   乾燥an aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate
5. 5
   その他the solvent was removed under reduced pressure

実験手順

Into 3 mL of a 90% aqueous trifluoroacetic acid solution, 156 mg of 1-(1,3-dioxolan-2-ylmethyl)-4-chloroquinolin-2(1H)-one was dissolved, and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure, and the reaction mixture was alkalified with an aqueous saturated sodium hydrogen carbonate solution, and then extracted with ethyl acetate. The organic layer was washed sequentially with water and an aqueous saturated sodium chloride solution, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 192 mg of a pale yellow oily substance, (4-chloro-2-oxoquinolin-1(2H)-yl)acetaldehyde.

出典