反応 #68003

反応方程式

1-(1,3-dioxolan-2-ylmethyl)-6-isopropylquinolin-2(1H)-one

trifluoroacetic acid

→

(6-isopropyl-2-oxoquinolin-1(2H)-yl)acetaldehyde

反応条件

後処理

1. 1
   その他The solvent was removed under reduced pressure, and ethyl acetate
2. 2
   workup.ADDITIONan aqueous saturated sodium hydrogen carbonate solution were added
3. 3
   その他The organic layer was separated
4. 4
   抽出the aqueous layer was extracted with ethyl acetate
5. 5
   洗浄the resultant solution was washed with an aqueous saturated sodium chloride solution
6. 6
   乾燥dried over anhydrous magnesium sulfate
7. 7
   その他the solvent was removed under reduced pressure

実験手順

To 0.42 g of 1-(1,3-dioxolan-2-ylmethyl)-6-isopropylquinolin-2(1H)-one, 4 mL of a 90% aqueous trifluoroacetic acid solution was added, and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure, and ethyl acetate and an aqueous saturated sodium hydrogen carbonate solution were added thereto. The organic layer was separated, and the aqueous layer was extracted with ethyl acetate. The organic layer and the extract were combined, the resultant solution was washed with an aqueous saturated sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure to obtain 0.41 g of a pale yellow oily substance, (6-isopropyl-2-oxoquinolin-1(2H)-yl)acetaldehyde.

出典