反応 #67887

反応方程式

tert-butyl-lithium

(R)-2-(3-(benzyloxy)benzyl)-4-(tert-butyldimethylsilyloxy)cyclopent-2-enone

copper cyanide

methyllithium

(S)-tert-butyl(1-iodooctan-3-yloxy)dimethylsilane

→

(2R,3R,4R)-2-(3-(benzyloxy)benzyl)-4-tert-butyldimethylsilyoxy-3-((S)-3-tert-butyldimethylsilyoxyoctyl)cyclopentanone

溶媒

ether

ether

ether

反応条件

後処理

1. 1
   温度A 25 ml two-necked flask was flame
2. 2
   その他dried
3. 3
   温度to be cooled
4. 4
   workup.ADDITIONadded to the reaction flask
5. 5
   その他The reaction was quenched with 40 ml saturated ammonium chloride (aq)
6. 6
   workup.ADDITIONcontaining 0.4 ml ammonium hydroxide
7. 7
   その他separated
8. 8
   抽出the aqueous layer was extracted with ethyl acetate
9. 9
   乾燥dried over anhydrous magnesium sulfate
10. 10
    ろ過The solid was filtered off
11. 11
    その他The solvent was evaporated off under vacuum
12. 12
    その他The crude product was purified by chromatography on silica gel using
13. 13
    workup.ADDITIONa mixture of hexane and ethyl acetate as a gradient eluent

実験手順

A 25 ml two-necked flask was flame dried and allowed to be cooled. (S)-tert-butyl(1-iodooctan-3-yloxy)dimethylsilane (1.18 g, 3.2 mmol) and 11.8 L ether were added to the reaction flask, followed by dropwise addition of tert-butyl-lithium (3.75 ml, 1.7M in pentane) at −70° C. A homogenous solution of copper cyanide (0.29 g, 3.2 mmol) and methyllithium (1.6 ml, 2M in ether) in 5.8 ml ether was cooled from room temperature to −70° C. and added to the reaction flask while stirring for 30 minutes. Then, a solution of (R)-2-(3-(benzyloxy)benzyl)-4-(tert-butyldimethylsilyloxy)cyclopent-2-enone (0.65 g, 1.6 mmol) in 6.5 ml ether at −70° C. was added to the reaction mixture for 30 minutes. The reaction was quenched with 40 ml saturated ammonium chloride (aq) containing 0.4 ml ammonium hydroxide. The reaction mixture was phase separated and the aqueous layer was extracted with ethyl acetate. The organic layers were combined and dried over anhydrous magnesium sulfate. The solid was filtered off. The solvent was evaporated off under vacuum. The crude product was purified by chromatography on silica gel using a mixture of hexane and ethyl acetate as a gradient eluent. Yield of the titled compound was 1.1 g (85%).

出典