反応 #6782

反応方程式

4-carboxyindole

2-chloro-1-methylpyridinium iodide

4-phenethylpiperazine

ethyldi-isopropylamine

→

(1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride

収率 100.1%

溶媒

acetone

N-methylpyrrolidone

NMP

反応条件

後処理

1. 1
   その他the crude product is obtained
2. 2
   その他the hydrochloride is precipitated
3. 3
   その他After drying

実験手順

A solution of 2.0 g of 4-carboxyindole and 8.1 g of 2-chloro-1-methylpyridinium iodide in 60 ml of N-methylpyrrolidone (NMP) is treated with a solution of 2.36 g of 4-phenethylpiperazine and 8.2 g of ethyldi-isopropylamine (EDIPA) in 20 ml of NMP and subsequently stirred at room temperature for 3 hours. The mixture is worked up in the customary manner and the crude product is obtained. This is dissolved in acetone and the hydrochloride is precipitated using aqueous hydrochloric acid. After drying, 4.59 g of (1H-indol-4-yl)-(4-phenethylpiperazin-1-yl)methanone, hydrochloride, m.p. 289.3°, is obtained.

出典