反応 #67742

ord-a3f0d023a40840c9842acdb6e29f4f0e

反応方程式

COc1ccc(Cc2cccc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)n2)cc1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(4-methoxybenzyl)pyridin-2-yl)cyclopropanecarboxamide
Cc1ccccc1[CH2][Zn+].[Cl-]
(2-methylbenzyl)zinc(II) chloride
O=C(Nc1cccc(Br)n1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide
→
Cc1ccccc1Cc1cccc(NC(=O)C2(c3ccc4c(c3)OCO4)CC2)n1
1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-(2-methylbenzyl)pyridin-2-yl)cyclopropanecarboxamide

反応物

COc1ccc(Cc2cccc(NC(=O)C3(c4ccc5c(c4)OCO5)CC3)n2)cc1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(4-methoxybenzyl)pyridin-2-yl)cyclopropanecarboxamide
Cc1ccccc1[CH2][Zn+].[Cl-]
(2-methylbenzyl)zinc(II) chloride
O=C(Nc1cccc(Br)n1)C1(c2ccc3c(c2)OCO3)CC1
1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

1-(Benzo[d][1,3]dioxol-5-yl)-N-(6-(2-methylbenzyl)pyridin-2-yl)cyclopropanecarboxamide (VRT-810361) was synthesized using the procedure of 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-(4-methoxybenzyl)pyridin-2-yl)cyclopropanecarboxamide by reacting (2-methylbenzyl)zinc(II) chloride with 1-(benzo[d][1,3]dioxol-5-yl)-N-(6-bromopyridin-2-yl)cyclopropanecarboxamide.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08524910B2uspto-grants-2013_09