反応 #67679

ord-44bccb47b2ad49ba81ede3851351a3dc

反応方程式

CC(C)(Cc1ccccc1)OC(=O)C[C@H](O)C[C@H](O)CBr
(3R,5S)-2-methyl-1-phenylpropan-2-yl 6-bromo-3,5-dihydroxy-hexanoate
CC(C)(Cc1ccccc1)OC(=O)C[C@H](O)C[C@H](O)CCl
(3R,5S)-2-methyl-1-phenylpropan-2-yl 6-chloro-3,5-dihydroxy-hexanoate
→
CC(C)(Cc1ccccc1)OC(=O)C[C@H]1C[C@@H](CBr)OC(C)(C)O1
crude title compound
CC(C)(Cc1ccccc1)OC(=O)C[C@H]1C[C@@H](CBr)OC(C)(C)O1
2-methyl-1-phenylpropan-2-yl 2-((4R,6S)-6-(bromomethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate

反応物

—
crude compound
CC(C)(Cc1ccccc1)OC(=O)C[C@H](O)C[C@H](O)CBr
(3R,5S)-2-methyl-1-phenylpropan-2-yl 6-bromo-3,5-dihydroxy-hexanoate
CC(C)(Cc1ccccc1)OC(=O)C[C@H](O)C[C@H](O)CCl
(3R,5S)-2-methyl-1-phenylpropan-2-yl 6-chloro-3,5-dihydroxy-hexanoate

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

実験手順

The procedure was carried out in the same manner as in Example 5, except that the crude compound (3R,5S)-2-methyl-1-phenylpropan-2-yl 6-bromo-3,5-dihydroxy-hexanoate (21.0 g) prepared in Example 4 was used in place of the crude compound (3R,5S)-2-methyl-1-phenylpropan-2-yl 6-chloro-3,5-dihydroxy-hexanoate (21.1 g) prepared in Example 3. The crude title compound was obtained (22.5 g).

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US08524914B2uspto-grants-2013_09