反応 #676549

反応方程式

Water

lithium hydroxide monohydrate

Ethyl 2-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetate

hydrochloric acid

→

solid

収率 58.0%

2-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetic acid

収率 58.0%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他It was reacted at room temperature for 3 h
2. 2
   その他A solid precipitated
3. 3
   ろ過It was filtered
4. 4
   その他dried

実験手順

Ethyl 2-[1-[4-(2-naphthamido)benzyl]-1H-indazol-3-yl]acetate (226 mg, 0.488 mmol) was dissolved in tetrahydrofuran (10 mL), and in an ice bath 10 mL aqueous solution of lithium hydroxide monohydrate (62 mg, 1.48 mmol) was added. It was reacted at room temperature for 3 h, and the reaction was monitored to be complete by TLC. Water was added into the system, and adjusted to pH≈3-4 with diluted hydrochloric acid. A solid precipitated. It was filtered, and dried to obtain a white solid 123 mg, at a yield of 58%.

出典