反応 #67495

反応方程式

Et3N

5-bromovaleric acid chloride

decahydroquinoline

AcOEt

→

4-bromo-1-(octahydroquinolin-1-yl)butan-1-one

反応条件

後処理

1. 1
   洗浄The solution is then washed with water
2. 2
   抽出the water re-extracted twice with AcOEt
3. 3
   洗浄The pooled organic phases are sequentially washed with 5% solution of NaHCO3, 1N HCl and saturated ammonium chloride solution
4. 4
   乾燥Finally the organic phase is dried over anhydrous Na2SO4, it
5. 5
   ろ過is filtered
6. 6
   その他the solvent is evaporated under reduced pressure
7. 7
   その他1.2 g of a yellow oil, which was used without subsequent purification
8. 8
   その他are obtained

実験手順

1.37 mL (9.9 mmol) of Et3N and 0.5 mL (4.5 mmol) of 5-bromovaleric acid chloride are added to a solution of 1 mL (4.0 mmol) of the decahydroquinoline in AcOEt. The resulting solution is kept under stirring for 18 h at rt. The solution is then washed with water, and the water re-extracted twice with AcOEt. The pooled organic phases are sequentially washed with 5% solution of NaHCO3, 1N HCl and saturated ammonium chloride solution. Finally the organic phase is dried over anhydrous Na2SO4, it is filtered and the solvent is evaporated under reduced pressure. 1.2 g of a yellow oil, which was used without subsequent purification, are obtained.

出典