反応 #674350

ord-68070b0989f14e92b2ace10e73cc613e

反応方程式

COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
B4
COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
COC(=O)[C@H]1CCN1.Cl
A7
COC(=O)[C@H]1CCN1.Cl
(R)-Methyl Azetidine-2-carboxylate Hydrochloride
→
COC(=O)[C@H]1CCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
(R)-Methyl 1-[4-((3-(Sulfamoylmethyl)phenyl)amino)-1,3,5-triazin-2-yl]azetidine-2-carboxylate

反応物

COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
B4
COCC1CCCCN1c1ncnc(Nc2cccc(CS(N)(=O)=O)c2)n1
rac-3-[(4-(2-Methoxymethylpiperidin-1-yl)-1,3,5-triazin-2-yl)amino]-benzenemethanesulfonamide
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
A1
NS(=O)(=O)Cc1cccc(Nc2ncnc(Cl)n2)c1
3-[(4-Chloro-1,3,5-triazin-2-yl)amino]benzenemethanesulfonamide
COC(=O)[C@H]1CCN1.Cl
A7
COC(=O)[C@H]1CCN1.Cl
(R)-Methyl Azetidine-2-carboxylate Hydrochloride

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    その他B36 was prepared
  2. 2
    その他obtained as white crystals

実験手順

B36 was prepared following the general procedure reported for B4 using A1 and A7 and obtained as white crystals; yield: 60 mg (18%). MS (ES) C15H18N16O4S requires: 378. found: 379 (M+H)+.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US09226929B2uspto-grants-2016_01